Endocrine Abstracts

Objective: 17-alpha-hydroxyprogesterone caproate therapy during pregnancy has been associated with insulin resistance. The aim of this study was to highlight any possible association of 17OHP with insulin resistance in women with PCOS.Design: Forty-five women with PCOS underwent 75 g OGTT test and short Synachten test with sampling of stimulated 17OHP. Women were divided into two subgroups according to basal 17OHP cut-off level of 0.8 ng/ml.<p class=...

Introduction: Papillary thyroid microcarcinomas (PTMC) are usually considered low-risk tumors with favorable prognosis. However, a small percentage behaves aggressively and controversies exist for various prognostic factors. The aim of this study was to evaluate demographic and tumor specific characteristics related to PTMC invasiveness.Patients – methods: This is a retrospective study of 510 thyroidectomized patients with PTMC who were treated in t...

Introduction: Radiation-induced hypopituitarism has been well-described in childhood-onset brain tumour survivors, however in adults has received less attention. The aim of this study was to assess the pituitary-related outcomes following cXRT in adults with extra-sellar gliomas.Methods: We retrospectively collected longitudinal data regarding pituitary-related outcomes from medical records of 59 patients, diagnosed with extra-sellar gliomas in adulthood...

Introduction: Childhood-onset brain tumour (CO-BT) survivors demonstrate elevated standardized mortality rates for cardiac disease. Adverse lipid profile and body composition contribute to the increased cardiovascular risk. Little is known about the metabolic changes in long-term survivors of adult-onset brain tumours (AO-BT).Methods: We performed a cross-sectional study to compare cardiovascular risk parameters in CO-BT with AO-BT survivors and healthy ...

Introduction: There is strong evidence that adult survivors of childhood cancer have excess premature vascular morbidity and mortality, the pathophysiological mechanism of which remains unresolved.Methods: We undertook a cross sectional study to assess cardiovascular risk in long-term survivors of brain tumours following cranial irradiation compared with healthy matched controls. The following cardiovascular markers were measured: full lipid profile, fas...

Introduction: Radiation-induced hypopituitarism is a well-recognized complication of cranial radiotherapy (cXRT) for childhood brain tumours when the hypothalamo–pituitary axis is within the irradiation field. Few data are available for survivors of adult brain tumours who have received cranial irradiation.Methods: We retrospectively reviewed medical records of patients referred to Endocrinology following cXRT for primary non-pituitary brain tumours...

Introduction: Thyroid autoimmunity and diabetes mellitus type 2 (DM2) are the commonest endocrine disorders in the general population. The aim of the study was to investigate whether there is an association between thyroid autoimmunity and β-cell secretion in patients with impaired fasting glucose (IFG) and/or impaired glucose tolerance (IGT).Methods/design: 501 patients (381 females) 46.5±14.2 years with IFG and/or IGT and autoimmune thyroidit...

Introduction: Cushing’s syndrome is a rare (0.004%) hormonal disorder, which develops due to hypercortisolaemia. Cushing’s disease refers to a corticothroph cell pituitary tumour overproducing ACTH, which induces abnormally increased cortisol production from the adrenal glands. Cushing’s disease is a causative factor of osteoporosis, hypertension, glucose intolerance and dyslipidaemia.Case report: A 50-year old woman was referred to our de...

Introduction: The polycystic ovary syndrome (PCOS) is a common and complex disease without a clear pattern of inheritance. There is evidence that PCOS is affected by both genetic and environmental factors, but there is no single and unambiguous explanation for its pathogenesis. Anti-Müllerian-inhibiting hormone (AMH) has an inhibitory effect on FSH-stimulated follicle growth and it has also been shown that serum AMH levels are higher in women with PCOS than in normovulato...

Objective: To evaluate the results of laparoscopic adrenalectomy in our institutions.Methods: Prospectively collected data from 2000 to 2007.Results: During the 8-year study period, 160 laparoscopic adrenalectomies were performed in 150 patients. Mean age was 49.8 years (female: 60.7%). Twenty-seven patients (18%) had previous open abdominal operations. There were 10 bilateral (6.6%) for Cushing’s disease, 64 right (42.7%) and...